• HOME
  • People
  • Projects
Doerschuk Research Group

Image Gallery

An icosahedron with one of each type of symmetry axis (2-, 3-, and 5-fold) shown and example angular basis functions with l=15 and p∈{1,…Nrep} . More info can be found here http://ieeexplore.ieee.org/abstract/document/7591598/
Four simulated real space 2D images of HK97. More info can be found here https://arxiv.org/pdf/1611.06618.pdf
The equilibrium configuration of the spring-and-mass mechanical model. More info can be found here http://ieeexplore.ieee.org/abstract/document/7532942/
Subunit-specific dynmic properties of NvV maturation intermediates. (a) Time resolved NvV maturation data sets were used to extract dynamic information from Cryo-EM reconstruction using the variance method. The structural models of capsids at each maturation state were solved de novo using the maximum likelihood algorithm that explicitly takes into account the continuous variability of the particles present in the data set. The result describes the heterogeneity of the particle as a variance plotted at every voxel of the reconstructed density. This new methodological approach allowed the analysis of the whole particle dynamics during maturation, as shown by the surface coloring of the capsids. (b) The graphs show that the variance computed for voxels corresponding to 10 A˚ around the cleavage site of the four quasi-equivalent positions. This analysis confirmed that maturation is clearly asymmetric. A and D subunits cleavage sites are the first to be stabilized, accounting for 50% of the subunits cleaved after 30 min in pH 5.0 (see cleavage kinetic in Figure 4a). B and C take longer to get in position and form the slow component of the kinetic curve. (c) The cut-way view of the mature capsid (three days) was colored with a different heat-map scale to reveal the relatively high dynamic region in the center of the capsid pentamers. Compare the position of gamma peptides shown in ribbon on the same cut way view of the protein capsid shell derived from the crystal structure reconstruction. More info can be found here https://www.sciencedirect.com/science/article/pii/S1879625716300153
Statistical-characterization-of-ensembles-of-symmetric-virus-particles. More info can be found here http://ieeexplore.ieee.org/abstract/document/7591598/
Cross sections of the standard deviation function sρ(x) for PhIPro+ using both Hetero (SymPart) and Hetero (SymStat) and displayed with a common color map.
Cross section of the standard deviation function sρ(x) for HK97 Prohead I+pro using both HRISS and HRSIS and displayed with a common color map.
3-D reconstructions of the standard deviation sρ(x) for PhIPro+.https://arxiv.org/abs/1701.01206
Theme by Colorlib Powered by WordPress